Transporters and drug delivery system using the same
AssigneeSanten Pharmaceutical Co., Ltd.
InventorsMitsuaki Kuwano, Masaki Nakagawa, Hiroshi Suhara
Life of this patent
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Abstract
An object of the present invention is to prepare substances which are excellent in delivery and enable drugs to be retained in a body effectively over a long period and to construct a drug delivery system using the substances. When the delivering substance which is obtained by reacting polyalkylene glycol or a reactive derivative thereof, a phospholipid and a drug with each other to form covalent bonds is administered systemically or topically, the substance is retained at a target site in a body for a long period, thereby making it possible to sustain drug efficacy over a long period by a single administration.
Claims20
A delivering substance comprising polyalkylene glycol or a reactive derivative thereof, a phospholipid and a drug linked by covalent bonds.
A delivering substance, represented by the following general formula [1], comprising polyalkylene glycol or a reactive derivative thereof, a phospholipid and a drug linked by covalent bonds,
- (A[Parenopenst]m—X—Y—[Parenclosest]B)n [1]
- wherein A and B, being the same or different, are residues of the drug, X is a residue of polyalkylene glycol or the reactive derivative thereof, Y is a phospholipid skeleton or a residue of the phospholipid, m is 0 or an integer of 1 or more, n is 0, 1 or 2, at least one of m and n is not 0, and all of A, B, X and Y are linked by the covalent bonds.
A drug delivery system characterized by administering systemically or topically a delivering substance which is obtained by reacting polyalkylene glycol or a reactive derivative thereof, a phospholipid and a drug with each other to form covalent bonds.
A drug delivery system characterized by instilling a delivering substance which is obtained by reacting polyalkylene glycol or a reactive derivative thereof, a phospholipid and a drug with each other to form covalent bonds.
A drug delivery system to a vitreous body, a retina or an optic nerve characterized by administering to the vitreous body a delivering substance which is obtained by reacting polyalkylene glycol or a reactive derivative thereof, a phospholipid and a drug with each other to form covalent bonds.
A method of treatment comprising administering to a patient systemically or topically a pharmaceutically effective amount of a delivering substance comprising polyalkylene glycol or a reactive derivative thereof, a phospholipid and a drug linked by covalent bonds solely or combined with a pharmaceutically acceptable carrier or additive.
A method of treating ophthalmopathy comprising instilling a pharmaceutically effective amount of a delivering substance comprising polyalkylene glycol or a reactive derivative thereof, a phospholipid and a drug linked by covalent bonds solely or combined with a pharmaceutically acceptable carrier or additive.
A method of treating a disease of a vitreous body, a retina or an optic nerve comprising administering to the vitreous body a pharmaceutically effective amount of a delivering substance comprising polyalkylene glycol or a reactive derivative thereof, a phospholipid and a drug linked by covalent bonds solely or combined with a pharmaceutically acceptable carrier or additive.
Dependencies are inferred from the claim text.