Antisense modulation of MEKK4 expression
OwnerDonna T. Ward, William Gaarde +2inventors
InventorsDonna T. Ward, William Gaarde, Brett P. Monia, Jacqueline Wyatt
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of MEKK4. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MEKK4. Methods of using these compounds for modulation of MEKK4 expression and for treatment of diseases associated with expression of MEKK4 are provided.
Claims20
A compound 8 to 50 nucleobases in length targeted to a nucleic acid molecule encoding MEKK4, wherein said compound specifically hybridizes with and inhibits the expression of MEKK4.
A compound 8 to 50 nucleobases in length which specifically hybridizes with at least an 8-nucleobase portion of an active site on a nucleic acid molecule encoding MEKK4.
Dependencies are inferred from the claim text.