Antisense modulation of Smad6 expression
OwnerBrett P. Monia, Lex M. Cowsertinventors
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of Smad6. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Smad6. Methods of using these compounds for modulation of Smad6 expression and for treatment of diseases associated with expression of Smad6 are provided.
Claims18
A compound 8 to 50 nucleobases in length targeted to a nucleic acid molecule encoding Smad6, wherein said compound specifically hybridizes with and inhibits the expression of Smad6.
A compound 8 to 50 nucleobases in length which specifically hybridizes with at least an 8-nucleobase portion of an active site on a nucleic acid molecule encoding Smad6.
Dependencies are inferred from the claim text.