Antisense strategy to modulate estrogen receptor response (ER alpha and/or ER beta)

A pharmaceutical composition comprising a pharmaceutically acceptable carrier and an antisense oligonucleotide complementary to a gene encoding a mammalian vascular estrogen receptor (ER) selected from the group comprising ER-alpha and ER-beta, wherein said antisense oligonucleotide comprises about 15 to 20 nucleotides complementary to said gene.

An antisense oligonucleotide comprising the nucleotide sequence of SEQ ID NO:

• 1, or a degenerate variant of SEQ ID NO:
• 1.

An antisense oligonucleotide comprising the nucleotide sequence of SEQ ID NO:

• 2, or a degenerate variant of SEQ ID NO:
• 2.

An antisense oligonucleotide comprising the nucleotide sequence of SEQ ID NO:

• 3, or a degenerate variant of SEQ ID NO:
• 3.

An antisense oligonucleotide comprising the nucleotide sequence of SEQ ID NO:

• 4, or a degenerate variant of SEQ ID NO:
• 4.

An antisense oligonucleotide comprising the nucleotide sequence of SEQ ID NO:

• 5, or a degenerate variant of SEQ ID NO:
• 5.

An antisense oligonucleotide comprising the nucleotide sequence of SEQ ID NO:

• 6, or a degenerate variant of SEQ ID NO:
• 6.

An antisense oligonucleotide comprising the nucleotide sequence of SEQ ID NO:

• 7, or a degenerate variant of SEQ ID NO:
• 7.

An antisense oligonucleotide comprising the nucleotide sequence of SEQ ID NO:

• 8, or a degenerate variant of SEQ ID NO:
• 8.

An antisense oligonucleotide comprising the nucleotide sequence of SEQ ID NO:

• 9, or a degenerate variant of SEQ ID NO:
• 9.

An antisense oligonucleotide comprising the nucleotide sequence of SEQ ID NO:

• 10, or a degenerate variant of SEQ ID NO:
• 10.

An antisense oligonucleotide comprising the nucleotide sequence of SEQ ID NO:

• 11, or a degenerate variant of SEQ ID NO:
• 11.

An antisense oligonucleotide comprising the nucleotide sequence of SEQ ID NO:

• 12, or a degenerate variant of SEQ ID NO:
• 12.

An antisense oligonucleotide comprising the nucleotide sequence of SEQ ID NO:

• 13, or a degenerate variant of SEQ ID NO:
• 13.

An antisense oligonucleotide comprising the nucleotide sequence of SEQ ID NO:

• 14, or a degenerate variant of SEQ ID NO:
• 14.

A kit as defined in claim 40 for use in the diagnosis of an ailment that is characterized by the modulation of estrogen receptor expression.