Novel specific inhibitor of the cyclin kinase inhibitor p21 (wafl/cip1)
OwnerRobert H Weissinventor
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Abstract
Methods and compositions for regulating abnormal cell growth and proliferation mediated by p21Waf1/Cip1 using inhibitors of p21Waf1/CiP1.
Claims39
A method for inhibiting cyclin-dependent kinase-mediated cell growth and proliferation, comprising inhibiting p21Waf1/Cip1 protein with a p21Waf1/Cip1 inhibitory agent in an amount effective to inhibit cell growth and proliferation.
A method of inhibiting a disease associated with abnormal cell growth and proliferation, comprising inhibiting p21Waf1/Cip1 protein by administering a p21Waf1/Cip1 inhibitory agent in an amount effective to inhibit cell growth and proliferation.
A method of inhibiting angiogenesis, comprising inhibiting p21Waf1/Cip1 protein by administering a p21Waf1/Cip1 inhibitory agent in an amount effective to inhibit angiogensis in tumors.
A method of inhibiting the growth of tumor cells, comprising administering to a patient an p21Waf1/Cip1 inhibitory agent in an amount effective to inhibit growth of the tumor cells.
A pharmaceutical composition comprising a p21Waf1/Cip1 inhibitory agent.
Dependencies are inferred from the claim text.