4'-thio-L-xylofuranosyl nucleosides, precursors thereof, preparation and use thereof
AssigneeSouthern Research Institute
InventorsJohn A. Secrist III, Kamal N. Tiwari, John A. Montgomery
Life of this patent
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Abstract
Compounds represented by the formula 1: 1 A is selected from the group consisting of 2 wherein each R individually is H or acyl, Y is X, N3, NH2, monoalkylamino, or dialkylamino; Z is O or S; and X is selected from the group consisting of hydrogen, halo, hydroxy, alkoxy, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, amino, monoalkylamino, dialkylamino, thioaryl, thioalkyl, allylamino, cyano and nitro; tautomers thereof; and pharmaceutically acceptable salts thereof are provided along with methods for their fabrication. Various of these compounds can be used as anticancer agents, or antiviral agents or to inhibit DNA replication.
Claims20
Compounds represented by the formula 1:
- 7
- wherein each R individually is H, or an acyl group;
- A is selected from the group consisting of
- 8
- wherein Y is X, N3, NH2, monoalkylamino or dialkylamino;
- Z is O or S;
- and
- X is selected from the group consisting of hydrogen, halo, hydroxy, alkoxy, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynl, amino, monoalkylamino, dialkylamino, thioaryl, thioalkyl, allylamino, cyano and nitro;
- tautomers thereof;
- and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.