PON3 and uses thereof
AssigneeThe Regents of the University of Michigan
InventorsBert N. La Du, Dragomir I. Draganov, Phillip L. Stetson, Catherine E. Watson
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Abstract
The present invention relates to paraoxonase genes, in particular PON3. The present invention provides isolated nucleotide sequence encoding PON3, wild type and mutant PON3 peptides. The present invention also provides methods for using PON3 to screen compounds for the ability to alter PON3 associated activities, methods for generating antibodies useful in the detection of PON3, and methods of treating and preventing oxidative damage, sepsis, chemical toxicity, and other conditions.
Claims22
A composition comprising a nucleic acid sequence comprising at least a portion of a gene encoding rabbit PON-3.
A composition comprising a nucleic acid sequence comprising a PON-3 variant.
A composition comprising a biological active rabbit PON3 polypeptide or polypeptide fragment thereof.
A method comprising:
- a) providing:
- i) a biologically active PON3 polypeptide or polypeptide fragment thereof;
- ii) a host;
- and
- iii) a delivery system;
- b) administering said biologically active rabbit PON3 polypeptide or fragment thereof to said host using said delivery system.
Dependencies are inferred from the claim text.