US 2003/0144214 A1 · Alkyl amino acid derivatives useful as pharmaceutical agents

Abstract

GABA-related pro-drugs of the formula (III) are provided that when administered to humans or other mammals provide an increased duration of active compound in the plasma compared to compounds of corresponding structure in which labile groups are not present. The compounds are of the formula (III) 1 In the above formula: P represents hydrogen or methyl; Q represents a labile amine- or amide-forming organic group that becomes removed in the human or animal body; R1 represents straight or branched C2-C6 alkyl, C3-C6 cycloalkyl or phenyl; R2 represents hydrogen or methyl; and R3 represents hydrogen, methyl or carboxyl; and R4 represents hydrogen or a labile ester-forming group selected from substituted and unsubstituted C1-C6 alkyl, benzyl and phenyl groups that become removed in the human or animal body. In the above formula when R1 is phenyl, R2, R3 and R4 are not simultaneously hydrogen. Pharmaceutically acceptable salts of any salt-forming compound within the above class are also included. The compounds may be used to treat a range of neurological conditions, e.g. epilepsy and pain.

Claims33

Dependent claims

A compound of the formula (III)

15
in which:
P is hydrogen or methyl;
Q is a labile amine- or amide-forming organic group that becomes removed in the human or animal body;
R1 is straight or branched C2-C6 alkyl, C3-C6 cycloalkyl or phenyl;
R2 is hydrogen or methyl;
and
R3 is hydrogen, methyl or carboxyl;
and
R4 is hydrogen or a labile ester-forming group selected from substituted and unsubstituted C1-C6 alkyl, benzyl and phenyl groups that become removed in the human or animal body,
or a pharmaceutically acceptable salt of any salt-forming compound within the above class,
but excluding compounds in which R1 is phenyl and R2, R3 and R4 are each hydrogen.

9 more elements

Dependencies are inferred from the claim text.

Alkyl amino acid derivatives useful as pharmaceutical agents

Life of this patent

Alkyl amino acid derivatives useful as pharmaceutical agents

Life of this patent

Abstract

Claims33