Combination therapy of angiotensin converting enzyme inhibitor, side-effect reduced amount of aldosterone antagonist and diuretic for treatment of cardiovascular disease
AssigneeG.D. Searle & Co.
InventorAlfonso T. Perez
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Abstract
Combinations of an ACE inhibitor, an aldosterone receptor antagonist and a diuretic are described for use in treatment of circulatory disorders. Of particular interest are therapies using captopril or enalapril co-administered with a low-dose of spironolactone and furosemide. This co-therapy would be particularly useful to treat congestive heart failure while avoiding or reducing aldosterone-antagonist-induced side effects such as hyperkalemia.
Claims25
A combination comprising a therapeutically-effective amount of an angiotensin converting enzyme inhibitor, an aldosterone receptor antagonist and a diuretic, said aldosterone receptor antagonist being present in an amount which is therapeutically effective to antagonize aldosterone but which amount is not sufficient for said aldosterone receptor antagonist to induce an adverse side effect.
A co-therapy for treating cardiovascular disorders in a subject afflicted with or susceptible to multiple cardiovascular disorders, wherein said co-therapy comprises administering a therapeutically-effective amount of an angiotensin converting enzyme inhibitor, and a diuretic agent, and administering an aldosterone receptor antagonist in an amount therapeutically effective to antagonize aldosterone but insufficient to induce an adverse side effect.
Dependencies are inferred from the claim text.