Polymer stabilized neuropeptides
AssigneeShearwater Corporation
InventorsMichael David Bentley, Michael James Roberts
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Abstract
A substantially hydrophilic conjugate is provided having a peptide that is capable of passing the blood-brain barrier covalently linked to a water-soluble nonpeptidic polymer such as polyethylene glycol. The conjugate exhibits improved solubility and in vivo stability and is capable of passing the blood-brain barrier of an animal.
Claims29
A substantially hydrophilic conjugate comprising a peptide covalently linked to a water-soluble, nonpeptidic polymer, wherein said peptide is stabilized in circulation and said conjugate can transport across the blood-brain barrier of a mammal.
A method for delivering a peptide into the brain of an animal through the blood-brain barrier comprising:
- providing a conjugate between a peptide and a water-soluble polymer, non-peptidic polymer;
- administering said conjugate into the blood stream of an animal;
- and
- transporting the conjugate across the blood-brain barrier of said animal.
The method of claim 18, wherein said peptide is an analgesic peptide.
A method for delivering into the brain of an animal through the blood-brain barrier an agent that is incapable of crossing the blood-brain barrier comprising:
- providing a conjugate comprising a water-soluble, nonpeptidic polymer, a peptide that is transportable across the blood-brain barrier covalently linked to said polymer, and a nontransportable agent also covalently linked to the polymer;
- and
- administering the conjugate into the blood stream of said animal and transporting the conjugate across the blood-brain barrier of said animal.
Dependencies are inferred from the claim text.