Coadministration of transport protein with conjugated cobalamin to deliver agents
OwnerDouglas A. Collinsinventor
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Abstract
Cobalamin transport proteins are administered in combination with cobalamin coupled to a diagnostic or pharmaceutically active agents to increase the extent of absorption of the diagnostic or pharmaceutically active agent. Cobalamin transport proteins include, but are not limited to intrinsic factor, transcobalamin I, transcobalamin II and transcobalamin III. The combination of the cobalamin or cobalamin derivative with the cobalamin transport protein provides enhanced cellular uptake.
Claims36
A method for increasing the uptake of cobalamin-bound detectable or therapeutic agent to a host in need thereof comprising providing the cobalamin-bound detectable or therapeutic agent in combination with a cobalamin transport protein.
A composition comprising a cobalamin-bound detectable or therapeutic agent in combination with a cobalamin transport protein.
Dependencies are inferred from the claim text.