Long-acting hormone and growth factor compositions and uses thereof
AssigneeThe Trustees of Columbia University in the City of New York
InventorsJoyce Lustbader, Leslie Lobel
Life of this patent
Estimating the term…
Abstract
This invention provides VEGF-FSH compounds having increased serum half-lives relative to either native VEGF or FSH, in which both VEGF and FSH are biologically active. This invention also provides related compositions and methods for increasing fertility, egg production and spermatogenesis in a subject, as well as methods for increasing vascularization in a tissue, particularly in ovarian tissue.
Claims66
A composition of matter comprising (a) at least one subunit of a hormone or growth factor and (b) a half-life-increasing moiety, wherein the hormone or growth factor subunit and half-life-increasing moiety are covalently bound.
The composition of chain 11, wherein the carboxy-terminal portion of the β-hCG subunit comprises the amino acid sequence corresponding to positions 113-145 of the β-hCG subunit.
A composition of matter comprising (a) at least one subunit of a hormone or growth factor, (b) a half-life-increasing moiety, and (c) a moiety that specifically binds to cells of a predetermined tissue.
A composition of matter comprising (a) at least one subunit of a hormone or growth factor, (b) a β-FSH subunit, (c) an α-FSH subunit and (d) a half-life-increasing moiety, wherein the hormone or growth factor, the β-FSH subunit, the α-FSH subunit and the half-life-increasing moiety are covalently bound.
Dependencies are inferred from the claim text.