Composition of restricted cancer cells which produce cancer cell proliferation suppressive materials, and uses thereof
AssigneeThe Rogosin Institute
InventorsShirin Asina, Kanti Jain, Albert L. Rubin, Barry Smith, Kurt Stenzel
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Abstract
Compositions of matter are described which contain restricted cancer cells. When so restricted, the cells produce an unexpectedly high amount of material which suppresses cancer cell proliferation. The phenomenon crosses cancer type and species lines. Processes for making these compositions, and their use, are also described.
Claims53
Composition useful in suppressing proliferation of target cancer cells, produced by entrapping a sample of cancer cells in a biocompatible, proliferation-restrictive, selectively-permeable structure, culturing said structure in culture medium for a time sufficient to restrict the proliferation of said entrapped cancer cells, wherein said entrapped cancer cells produce cancer-cell proliferation suppressing material which suppresses proliferation of the target cancer cells and recovering the medium.
A process for making a composition which has a cancer cell proliferation-inhibiting effect, comprising culturing a biocompatible, proliferation-restrictive, selectively-permeable structure which has cancer cells entrapped therein in a medium for a time sufficient for said cancer cells to produce cancer-cell proliferation-suppressing material, and recovering the medium.
A method for suppressing the proliferation of cancer cells in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of biocompatible, proliferation-restrictive, selectively-permeable structures which contain restricted cancer cells from a species other than said subject, wherein said restricted cancer cells produce a material which suppresses cancer cell proliferation, in an amount sufficient to suppress cancer cell proliferation in said subject.
A method for suppressing proliferation of cancer cells in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of biocompatible, proliferation-restrictive, selectively-permeable structures which contain restricted cancer cells from the same species as said subject, wherein said restricted cancer cells produce a material which suppresses cancer-cell proliferation, in an amount sufficient to suppress cancer-cell proliferation in said subject.
A composition of matter comprising a biocompatible, proliferation-restrictive, selectively-permeable structure, said structure restricting cancer cells which produce more of a material which suppresses cancer cell proliferation compared to an equal number of the same cancer cells when unrestricted.
A process for preparing a biocompatible, proliferation-restrictive, selectively-permeable structure, comprising the steps of forming a structure by contacting cancer cells with biocompatable, proliferation-restrictive matter to form the structure, and culturing the structures for a sufficient period of time to restrict said cancer cells such that they produce a material which suppresses cancer cell proliferation compared to an equal number of unrestricted cancer cells of the same cancer type.
A method of increasing the production of material that suppresses cancer cell growth by a cancer cell, comprising restricting cancer cells with a structure-forming material to form a biocompatable, selectively-permeable, proliferation-restrictive structure and culturing the cancer cells until they are restricted.
Dependencies are inferred from the claim text.