Compositions and methods for treating ischemic stroke
OwnerHiroki Yokota, Hui Bin Sun +2inventors
InventorsHiroki Yokota, Hui Bin Sun, Zao C. Xu, Yiwen Ruan
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Abstract
Compositions and methods are provided for the treatment of ischemic stroke.
Claims23
An antisense molecule targeted to a nucleic acid molecule encoding a calcium-independent receptor for α-latrotoxin (CIRL), wherein said antisense molecule specifically hybridizes with said nucleic acid molecule encoding CIRL and inhibiting the expression of CIRL.
A pharmaceutical preparation for treating ischemic stroke, comprising an antisense oligonucleotide analog which enters hippocampal cells expressing CIRLs and binds specifically to a nucleic acid molecule encoding a CIRL, said antisense oligonucleotide being present in a biologically compatible medium.
An antibody which specifically binds to a calcium-independent receptor for α-latrotoxin (CIRL).
A method of identifying a CIRL-1 protein localization in the brain comprising
- a) providing an antibody which specifically binds to a calcium-independent receptor for α-latrotoxin (CIRL);
- b) contacting a brain tissue sample with said antibody, said antibody further comprising a detectable label;
- c) detecting said detectably-labeled antibody, thereby localizing said CIRL-1 protein in said brain tissue.
Dependencies are inferred from the claim text.