US 2003/0143732 A1Published application

RNA interference mediated inhibition of adenosine A1 receptor (ADORA1) gene expression using short interfering RNA

OwnerKathy Fosnaugh, James A. McSwiggeninventors

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Abstract

The present invention concerns methods and reagents useful in modulating adenosine A1 receptor (ADORA1) gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small interfering RNA (siRNA) molecules capable of mediating RNA interference (RNAi) against ADORA1 and related receptors.

Claims36

Dependent claims

A short interfering RNA (siRNA) molecule that down regulates expression of an ADORA1 gene by RNA interference.

Dependencies are inferred from the claim text.

Facts

Application: 10/224,005Filed 20 Aug 2002
Priority: 28 Aug 2001
Published: 31 Jul 2003
Term ends: Not estimatedThe source records don’t support an estimate.

Classification16 codes

C12N 15/1137
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming…: against enzymes
C12N 15/113
DNA or RNA fragments; Modified forms thereof ; Non-coding nucleic acids having a biological activity: non-coding nucleic acids modulating the…
C12N 15/1138
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming…: against…
A61K 38/00
Medicinal preparations containing peptides

Family

Application60/315,315Us provisional application · filed 28 Aug 2001
US 2003/0143732 A1This patent

From the US filing history. Foreign family members aren’t listed.

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