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US 2003/0143699 A1Published application
Process for the preparation of optically active azabicyclo heptanone derivatives
AssigneeCouncil of Scientific and Industrial Research
InventorsRohini Ramesh Joshi, Asmita Ashutosh Prabhune, Ramesh Anna Joshi, Mukund Keshav Gurjar
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Abstract
The present invention provides a process for preparation of optically active azabicyclo heptanone derivatives using lactamases that will react with racemic −lactam of formula (I) to give a single enantiomer of lactam (III) and the corresponding ring opened compound of formula (IV) in an enantiomerically pure form. 1
Claims15
A process for the preparation of optically active azabicyclo heptanone derivative of general formula III wherein R1═H, X═CH2Y—Z═—CH═CH—
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- which comprises reacting (±)2-aza-bicyclo[2,2,1]hept-5-en-3-one of formula I
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- Wherein R1═H, COR2(R2=C1-4 alkyl,C1-4 alkoxy,aryl,aryloxy) X═O,CHR3 (R3=F,OH,Br,H)
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- with an enzyme or whole cell in a buffer containing organic solvent at temperature ranging between 25-30° C. for a period ranging from 10-24 hr., extracting the mixture with an organic solvent, separating the organic layer, and removing the solvent.
3 more elements
Dependencies are inferred from the claim text.