US 2003/0143698 A1Published application

Process for the enzymatic preparation of enantiopure 1, 3-dioxolan-4-one and 1,3-oxathiolan-5-one derivatives

AssigneeConsortium fur Elektrochemische Industrie GmbH

InventorsAlfred Popp, Jurgen Stohrer, Hermann Petersen, Andrea Gilch, Jodoca Rockinger-Mechlem

Life of this patent

Estimating the term…

Loading patent…

Abstract

A process is provided for preparing an enantiopure 1,3-dioxolan-4-one or 1,3-oxathiolan-5-one derivative, which includes bringing a mixture containing enantiomeric 1,3-dioxolan-4-one or 1,3-oxathiolan-5-one derivatives and an enzyme with hydrolytic activity into contact in the presence of a nucleophile. Cleaving a dioxolanone/oxathiolanone ring of one enantiomer occurs by the enzyme with hydrolytic activity and, after the cleavage of one enantiomer has taken place, the uncleaved enantiomer of the 1,3-dioxolan-4-one or 1,3-oxathiolan-5-one derivative is isolated.

Claims14

Dependent claims

A process for preparing an enantiopure 1,3-dioxolan-4-one derivative or an enantiopure 1,3-oxathiolan-5-one derivative, which comprises

bringing a mixture containing a substance selected from the group consisting of an enantiomeric 1,3-dioxolan-4-one derivative and an enantiomeric 1,3-oxathiolan-5-one derivative and an enzyme with hydrolytic activity into contact in the presence of a nucleophile;
cleaving a ring of one enantiomer selected from the group consisting of the 1,3-dioxolan-4-one ring and the 1, 3-oxathiolan-5-one ring by the enzyme with hydrolytic activity;
and,
after the cleaving of one enantiomer has taken place, isolating an uncleaved enantiomer selected from the group consisting of the 1,3-dioxolan-4-one derivative and 1,3-oxathiolan-5-one derivative.

1 more element

Dependencies are inferred from the claim text.