Receptor based antagonists and methods of making and using
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsNeil Stahl, George D. Yancopoulos
Life of this patent
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Abstract
The present invention provides a fusion polypeptide capable of binding a cytokine to form a nonfunctional complex. It also provides a nucleic acid sequence encoding the fusion polypeptide and methods of making and uses for the fusion polypeptide.
Claims57
An isolated nucleic acid molecule having the sequence set forth in SEQ ID NO:
- 33 encoding a fusion polypeptide having the sequence set forth in SEQ ID NO:
- 34, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.
An isolated nucleic acid molecule having the sequence set forth in SEQ ID NO:
- 35 encoding a fusion polypeptide having the sequence set forth in SEQ ID NO:
- 36, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.
An isolated nucleic acid molecule having the sequence set forth in SEQ ID NO:
- 37 encoding a fusion polypeptide having the sequence set forth in SEQ ID NO:
- 38, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.
An isolated nucleic acid molecule having the sequence set forth in SEQ ID NO:
- 39 encoding a fusion polypeptide having the sequence set forth in SEQ ID NO:
- 40, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.
An isolated nucleic acid molecule having the sequence set forth in SEQ ID NO:
- 41 encoding a fusion polypeptide having the sequence set forth in SEQ ID NO:
- 42, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.
An isolated nucleic acid molecule having the sequence set forth in SEQ ID NO:
- 43 encoding a fusion polypeptide having the sequence set forth in SEQ ID NO:
- 44, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.
An isolated nucleic acid molecule having the sequence set forth in SEQ ID NO:
- 45 encoding a fusion polypeptide having the sequence set forth in SEQ ID NO:
- 46, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.
An isolated nucleic acid molecule having the sequence set forth in SEQ ID NO:
- 47 encoding a fusion polypeptide having the sequence set forth in SEQ ID NO:
- 48, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.
An isolated nucleic acid molecule having the sequence set forth in SEQ ID NO:
- 49 encoding a fusion polypeptide having the sequence set forth in SEQ ID NO:
- 50, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.
An isolated nucleic acid molecule having the sequence set forth in SEQ ID NO:
- 51 encoding a fusion polypeptide having the sequence set forth in SEQ ID NO:
- 52, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.
An isolated nucleic acid molecule having the sequence set forth in SEQ ID NO:
- 53 encoding a fusion polypeptide having the sequence set forth in SEQ ID NO:
- 54, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.
An isolated nucleic acid molecule having the sequence set forth in SEQ ID NO:
- 55 encoding a fusion polypeptide having the sequence set forth in SEQ ID NO:
- 56, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.
Dependencies are inferred from the claim text.