Methods and compositions for modulating integrin-mediated cell-cell interactions
OwnerCarlos Lopez-Otin, Jose Maria Perez Freije +4inventors
InventorsCarlos Lopez-Otin, Jose Maria Perez Freije, Santiago Cal Miguel, Jose Manuel Lopez Garcia, Albert Bernard Bianchi, Pamela Trail
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Abstract
Compositions and methods are provided for identifying and designing modulators of integrin-mediated cell-cell interactions through altering the interaction of ADAM 23 with αvβ3 integrin. Compositions and-methods are also provided for modulating integrin-mediated cell-cell interactions such as those involved in angiogenesis, induction of active metalloproteinases, tumor progression and neural tissue growth.
Claims20
An isolated nucleic acid sequence encoding ADAM 23.
A method for identifying modulators of integrin-mediated cell-cell interactions comprising contacting a host cell expressing ADAM 23 or a peptide thereof with a test agent and determining the ability of the test agent to alter interaction of ADAM 23 or the peptide with αvβ3 integrin wherein a test agent which alters the interaction of ADAM 23 or the peptide with αvβ3 integrin is identified as a modulator of integrin-mediated cell-cell interactions.
A synthetic peptide comprising SEQ ID NO:1 or a variant thereof which modulates the interaction of ADAM 23 with αvβ3 integrin.
A method of modulating integrin-mediated cell-cell interactions comprising contacting cells with a modulator which alters the interaction of ADAM 23 with αvβ3 integrin.
A method for inhibiting tumor progression in a patient comprising administering to the patient a modulator of the interaction of ADAM 23 with αvβ3 integrin.
A method for inducing growth of neural tissue comprising contacting neural tissue with a modulator of the interaction of ADAM 23 with αvβ3 integrin.
A composition which alters integrin-mediated cell-cell interactions comprising a modulator of the interaction of ADAM 23 with αvβ3 integrin.
A pharmaceutical composition for altering integrin-mediated cell-cell interactions comprising an effective amount of a modulator of the interaction of ADAM 23 with αvβ3 integrin and a pharmaceutically acceptable vehicle.
A composition which inhibits tumor progression comprising a modulator of the interaction of ADAM with αvβ3 integrin, wherein said modulator inhibits or antagonizes the interaction of ADAM with αvβ3 integrin.
A composition which induces growth of neural tissue comprising a modulator of the interaction of ADAM with αvβ3 integrin, wherein said modulator activates or agonizes the interaction of ADAM with αvβ3 integrin.
Dependencies are inferred from the claim text.