Human ataxin-1-like polypeptide IMX97018

An isolated polypeptide comprising an amino acid sequence selected from the group consisting of:

• (a) the amino acid sequence of SEQ ID NO:2;
• (b) an amino acid sequence selected from the group consisting of:
• amino acids 542 through 579 of SEQ ID NO:2, and amino acids 464 through 583 of SEQ ID NO:2;
• (c) an amino acid sequence selected from the group consisting of:
• amino acids 465 through 499 of SEQ ID NO:2, and amino acids 431 through 499 of SEQ ID NO:2;
• (d) an amino acid sequence selected from the group consisting of:
• amino acids 465 through 590 of SEQ ID NO:2, and amino acids 444 through 640 of SEQ ID NO:2;
• (e) a fragment of the amino acid sequences of any of (b)-(d) comprising at least 20 contiguous amino acids;
• (f) a fragment of the amino acid sequences of any of (a)-(d) having IMX97018 polypeptide self-association or RNA-binding activity;
• (g) a fragment of the amino acid sequences of any of (a)-(d) comprising AXH domain amino acid sequences;
• and
• (h) an amino acid sequence comprising at least 30 amino acids, having IMX97018 polypeptide self-association or RNA-binding activity, and sharing amino acid identity with the amino acid sequences of any of (b)-(g), wherein the percent amino acid identity is selected from the group consisting of:
• at least 80%, at least 85%, at least 90%, at least 95%, at least 97.5%, at least 99%, and at least 99.5%.