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OwnerDavid L. Kaplan, Paul Gatenholm +4inventors
InventorsDavid L. Kaplan, Paul Gatenholm, Karl Mattias Berglin, Joseph David Platko, Lauren Rebecca Pepper, Alyssa Vanita Ngangan
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The proteins involved in barnacle are useful in devising high-strength protein-based adhesives capable of curing under water, coatings for prosthetic implants to serve as an interface between the prosthetic and the bone or other tissue, and methods of preventing biofouling of underwater surfaces. DNA and amino acid sequences of the adhesion proteins are provided and isolated nucleic acid sequences and isolated proteins, vectors comprising such isolated nucleic acid sequences as well as microorganisms comprising such vectors and capable of expressing a barnacle adhesive protein are also provided.
An isolated nucleic acid sequence consisting essentially of Seq. ID No. 2 or Seq. ID No. 10.
An isolated nucleic acid sequence comprising Seq. ID No. 2 or Seq. ID No. 10.
An isolated nucleic acid sequence which is at least about 80 percent identical to a sequence selected from the group consisting of Seq. ID No. 2 and Seq. ID No. 10, wherein the nucleic acid sequence encodes a barnacle adhesive protein.
An isolated nucleic acid sequence encoding the protein of Seq. ID No. 1 or Seq. ID No. 9.
An isolated protein consisting essentially of Seq. ID No. 1 or Seq. ID No. 9.
An isolated protein comprising Seq. ID No.1 or Seq. ID No. 9.
An isolated protein consisting of Seq. ID No. 1 or Seq. ID No. 9.
A protein consisting essentially of an amino acid sequence that is at least about 80 percent identical to a sequence selected from the group consisting of Seq. ID No. 1 or Seq. ID No. 9, wherein said protein is capable of cross-linking with other barnacle cement proteins.
Dependencies are inferred from the claim text.