Guanosine triphosphate-binding protein coupled receptors
AssigneeNational Institute of Advanced Industrial
InventorsMakiko Suwa, Kiyoshi Asai, Yutaka Akiyama, Hiroyuki Aburatani
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Abstract
The object of the present invention is to provide a technique for efficiently extracting GPCR sequences from human genome sequences, thereby comprehensively identifying novel GPCRs. An original automatic system for identifying GPCR sequences is disclosed, and 1,215 novel GPCRs are successfully identified from the entire human genome by utilizing the system.
Claims29
A polynucleotide encoding a guanosine triphosphate-binding protein coupled receptor selected from the group of:
- (a) a polynucleotide encoding a polypeptide coprising an amino acide sequence selected from the group consisting of the even-numbered SEQ ID NOs from SEQ ID NO:
- 2 to SEQ ID NO:
- 2430;
- (b) a polynucleotide comprising a coding region of the ncleotide sequence selected from the group consisting of the odd-numbered SEQ ID NOs from SEQ ID NO:
- 1 to SEQ ID NO:
- 2429;
- (c) a polynucleotide encoding a polypeptide comprising an amino acid sequence selected from the group consisting of the even-numbered SEQ ID NOs from SEQ ID NO:
- 2 to SEQ ID NO:
- 2430 wherein one or more amino acid residues are substituted, deleted, added and/or inserted;
- and
- (d) a polynucleotide hybridizing under stringent conditions with a DNA consisting of a nucleotide sequence selected from the group consisting of the odd-numbered SEQ ID NOs from SEQ ID NO:
- 1 to SEQ ID NO:
- 2429.
A polynucleotide encoding a fragment of a polypeptide comprising an amino acid sequence selected from the group consisting of the even-numbered SEQ ID NOs from SEQ ID NO:
- 2 to SEQ ID NO:
- 2430.
Dependencies are inferred from the claim text.