Glycosulfopeptide inhibitors of leukocyte rolling and methods of use thereof
OwnerRichard D. Cummings, Rodger P. McEverinventors
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Abstract
Compounds, compositions and methods for treating conditions characterized by leukocyte rolling are described. The compounds contain glycosulfopeptide structures comprising sulfated tyrosines and sialyated, fucosylated N-acetyllactosamino glycans. The glycosulfopeptides may be conjugated or complexed to other compounds for enhancing serum half-life or for controlled release, for example. Examples of conditions treated include inflammation, ischemia-reperfusion injury, rheumatoid arthritis, atherosclerosis, leukocyte-mediated lung injury, restenosis, and thrombosis.
Claims6
A method of inhibiting or reducing leukocyte rolling in a subject in vivo, comprising:
- administering to the subject an effective amount of a compound comprising a glycosulfopeptide thereby inhibiting or reducing leukocyte rolling in the subject, the glycosulfopeptide comprising the structure:
- 6
- wherein C is an O-, N-, or S-linking amino acid;
- and
- wherein R is one of R1, R3-R13 or R15, wherein:
- 7 8 9 10
A composition for inhibiting or reducing leukocyte rolling in a subject in vivo, comprising:
- a pharmaceutically acceptable carrier;
- and
- a compound comprising a glycosulfopeptide comprising the structure:
- 11
- wherein, C is an O-, N-, or S-linking amino acid;
- and
- wherein, R is one of R1, R3-R13 or R15 wherein:
- 12 13 14 15
Dependencies are inferred from the claim text.