Haptens, immunogens, antibodies and conjugates to 2-oxo-3-hydroxy-LSD
AssigneeRandox :abpratproes :o, oted
InventorsRobert Ivan McConnell, Elouard Benchikh, Stephen Peter Fitzgerald, John Victor Lamont
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Abstract
The invention provides a hapten derivatised with a crosslinker at the nitrogen of the 8β-carboxamide of 2-oxo-3-hydroxy LSD. The invention also provides an immunogen comprising the aforementioned hapten coupled to an antigenicity-conferring carrier material; a conjugate comprising the aforementioned hapten coupled to a labelling agent, as well as, antibodies raised against the aforementioned immunogen and capable of binding with at least the 3-hydroxy-2-pyrrolidone structural epitope of 2-oxo-3-hydroxy LSD.
Claims30
A hapten having the following structural formula:
- 3
- wherein R is a bivalent link and X is a terminal group.
Antibodies having specificity for 2-oxo-3-hydroxy-LSD characterized by having cross-reactivity of less than 5% for both LSD and nor LSD.
Dependencies are inferred from the claim text.