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AssigneeCancer Research Campaign Technology Limited
InventorsRonald A. Laskey, Gareth H. Williams, Nicholas Coleman
Estimating the term…
Determination of cellular growth abnormality, particularly cancerous abnormality, by detection of target polypeptides or encoding mRNA, where the target polypeptides are members of the preinitiation complex of DNA replication in tissue, cells or fluid. Target polypeptides include CDC6, MCM2, MCM3, MCM4, MCM5, MCM6 and MCM7. Test samples include tissue of the cervix (both biopsy and smear samples), breast, colon, lung, bladder, skin, larynx, oesophagus, bronchus, lymph nodes and urinary tract (both biopsy and cytology smear samples), in determination of cancerous and precancerous cellular growth abnormality, and cells spun from urine, blood and serum, in determination of haematological malignancies and evidence of metastatic sarcoma and carcinoma.
A method of determining the presence or absence of abnormally proliferating cells or cellular growth abnormality in a sample from an individual, the method including detecting in the sample a target polypeptide, wherein the target polypeptide is a member of the preinitiation complex of DNA replication;
A method of determining the presence or absence of abnormally proliferating cells or cellular growth abnormality in a cervical sample from an individual, the method including contacting the sample with a specific binding member or specific binding members directed against a target polypeptide and determining binding of the specific binding member or members to the sample, wherein the target polypeptide is a member of the preinitiation complex of DNA replication.
A method of determining the presence or absence in an individual of abnormally proliferating cells or cellular growth abnormality, the method including detecting a target polypeptide, or mRNA encoding a target polypeptide, in tissue, fluid or cells of an individual, wherein the target polypeptide is a member of the preinitiation complex of DNA replication;
Dependencies are inferred from the claim text.