Antibody/carrier complex, process for producing the same, method of controlling antigen-antibody reaction by using the same and immunoassay method
OwnerMahito Hirai, Nobuyuki Shigetohinventors
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Abstract
An antibody/carrier complex which makes it possible to easily control the reactivity in an antigen-antibody reaction without producing a new antibody. This antibody/carrier complex is a complex containing at least one antibody and has a polymer structure wherein each antigen-binding site of the antibody is allowed to be arranged so as to react with the antigen.
Claims11
An antibody/carrier complex including at least one antibody, the antibody/carrier complex including a polymer structure wherein each antigen binding site of the antibody is allowed to be arranged so as to react with an antigen, and the carrier is water-soluble.
A method for adjusting the reactivity of an antigen-antibody reaction, comprising steps of:
- in a reaction of an antibody and a polymerization reagent, changing a parameter selected from a group consisting of the equivalent of the polymerization reagent with respect to the antibody, reaction temperature, reaction time, and the concentration of antibody, so as to obtain a plurality of antibody polymers having different degrees of polymerization;
- bonding the plurality of antibody polymers to carriers so as to obtain a set of antibody/carrier complexes;
- and
- selecting an antibody/carrier complex which reacts with an antigen at a desired degree of reaction, from the set of antibody/carrier complexes.
Dependencies are inferred from the claim text.