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US 2003/0143633 A1Published application
Factors participating in degranulation of mast cells, dnas encoding the same, method of screening of these factors and the inhibitors
AssigneeDainippon Pharmaceutical Co., Ltd.
InventorsTsuyoshi Yamada, Motoharu Ido
Life of this patent
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Abstract
The present invention provides a novel protein that regulates degranulation of mast cells (degranulation regulator), a gene encoding it, a protein (conjugate factor) that interacts with the regulator, a gene encoding it, a screening method of an inhibitor of the degranulation, which uses this degranulation regulator and the conjugate factor, an inhibitor obtained by the screening method and the like.
Claims41
A protein of the following (a), (b) or (c):
- (a) a protein having the amino acid sequence depicted in SEQ ID NO:
- 1,
- (b) a protein having an amino acid sequence which is the amino acid sequence of the above-mentioned (a), wherein one to several amino acids are substituted, deleted, inserted, added or modified, and capable of regulating degranulation of mast cells on its own or by interaction with one or more conjugate factors,
- (c) a fragment of the protein of the above-mentioned (a), which is a protein capable of regulating degranulation of mast cells on its own or by interaction with one or more conjugate factors.
1 more element
A protein of the following (a), (b) or (c):
- (a) a protein having the amino acid sequence depicted in SEQ ID NO:
- 4,
- (b) a protein having an amino acid sequence which is the amino acid sequence of the above-mentioned (a), wherein one to several amino acids are substituted, deleted, inserted, added or modified, and capable of regulating degranulation of mast cells on its own or by interaction with one or more conjugate factors,
- (c) a fragment of the protein of the above-mentioned (a), which is a protein capable of regulating degranulation of mast cells on its own or by interaction with one or more conjugate factors.
1 more element
Dependencies are inferred from the claim text.