Compositions and methods of production and use of polydiazoaminotyrosine
OwnerEric A. Holwittinventor
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Abstract
The present invention concerns compositions, methods of production and methods of use of polydiazoaminotyrosine (DAT), a novel organic semiconductor. In preferred embodiments, the DAT is oxidized (O-DAT). In certain embodiments, recognition complexes comprising DAT operably coupled to a binding moiety are provided. The recognition complexes are of use for detection, identification and/or neutralization of various analytes. In alternative embodiments, DAT in combination with a source of activating radiation may be used to neutralize various analytes, such as anthrax spores.
Claims27
A composition comprising polydiazoaminotyrosine (DAT).
A recognition complex system comprising two or more recognition complexes, each recognition complex comprising DAT operably coupled to a binding moiety.
A method for obtaining one or more binding moieties that bind with high affinity for an analyte comprising the steps of:
- a) generating multiple recognition complexes, each recognition complex comprising a binding moiety operably coupled to DAT;
- b) contacting the recognition complexes with the analyte;
- c) separating those recognition complexes that bind to the analyte from those recognition complexes that do not bind to the analyte;
- and
- d) repeating (b) and (c) until one or more binding moieties that bind with high affinity to the analyte are obtained.
A method for neutralizing an infectious agent comprising the steps of:
- a) contacting the infectious agent with DAT;
- and
- b) activating the DAT.
A method of producing DAT comprising
- a) obtaining a solution of 3-amino-L-tyrosine (3-AT);
- and
- b) contacting the 3-AT with an alkali metal nitrite.
Dependencies are inferred from the claim text.