Human RNA binding proteins
AssigneeIncyte Genomics, Inc.
InventorsOlga Bandman, Y. Tom Tang, Neil C. Corley, Karl J. Guegler, Dyung Aina M. Lu, Mariah R. Baughn
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Abstract
The invention provides human RNA binding proteins (RNABP) and polynucleotides which identify and encode RNABP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of RNABP.
Claims61
An isolated polypeptide selected from the group consisting of:
- a) a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:1-3,
- b) a polypeptide comprising a naturally occurring amino acid sequence at least 90% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:1-3,
- c) a biologically active fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:1-3, and
- d) an immunogenic fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:1-3.
An isolated polynucleotide selected from the group consisting of:
- a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO:4-6,
- b) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 85% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO:4-6,
- c) a polynucleotide complementary to a polynucleotide of a),
- d) a polynucleotide complementary to a polynucleotide of b), and
- e) an RNA equivalent of a)-d).
A composition comprising a polypeptide of claim i and a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.