CaESS1: a Candida albicans gene, methods for making and using, and targeting it or its expression products for antifungal applications
AssigneeHealth Research, Inc.
InventorsSteven D. Hanes, Gina Devasahayam, Vishnu Chaturvedi
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Abstract
Disclosed and claimed is the CaESS1 gene, portions thereof such as primers or probes, expression products therefrom, and methods for using the gene, and expression products; for instance, for diagnostic, therapeutic or preventive compositions.
Claims23
An isolated or purified nucleic acid molecule comprising a nucleotide sequence encoding CaEss1, or having at least 70% homology thereto.
An isolated or purified polypeptide comprising an amino acid sequence having the enzymatic activity of CaEss1, or at least 70% homology thereto.
A compound which inhibits Candida albicans by inhibiting CaEss1 or CaESS1.
An antiproliferative compound which selectively inhibits growth of yeast transformed to contain and express PIN1 and not an endogenous ESS1, and this inhibition can be overcome by high levels of PIN1 expression.
A method for obtaining an isolated nucleic acid molecule encoding CaEss1 comprising performing a polymerase chain reaction on a sample suspected to contain CaESS1 using primers or probes which specifically hybridize thereto.
Dependencies are inferred from the claim text.