US 2003/0143589 A1Published application

Drug metabolizing enzymes

AssigneeIncyte Genomics, Inc.

InventorsMariah R. Baughn, Christopher M. Bruns, Debopriya Das, Li Ding, Vicki S. Elliott, Ameena R. Gandhi, April J.A. Hafalia, Liam Kearney, Farrah A. Khan, Preeti G. Lal, Ernestine A. Lee, Dyung Aina M. Lu, Yan Lu, Danniel B. Nguyen, Chandra S. Arvizu, Jayalaxmi Ramkumar, Huijun Z. Ring, Madhusudan M. Sanjanwala, Y. Tom Tang, Kavitha Thangavelu, Michael B. Thornton, Catherine M. Tribouley, Narinder K. Chawla, Yuming Xu, Junming Yang, Monique G. Yao, Henry Yue

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Abstract

The invention provides human drug metabolizing enzymes (DME) and polynucleotides which identify and encode DME. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of DME.

Claims80

Dependent claims

An isolated polypeptide selected from the group consisting of:

a) a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:1-18,
b) a polypeptide comprising a naturally occurring amino acid sequence at least 90% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:1-18,
c) a biologically active fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:1-18, and
d) an immunogenic fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:1-18.

1 more element

Dependencies are inferred from the claim text.

Facts

Application: 10/274,694Filed 18 Oct 2002
Priority: 7 Jul 2000
Published: 31 Jul 2003
Term ends: Not estimatedThe source records don’t support an estimate.

Classification67 codes

C12N 9/00
Enzymes
A61P 1/04
Drugs for disorders of the alimentary tract or the digestive system: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of…
A61P 1/08
Drugs for disorders of the alimentary tract or the digestive system: for nausea, cinetosis or vertigo; Antiemetics
A61P 1/10
Drugs for disorders of the alimentary tract or the digestive system: laxatives

Family

Application60/216,804Us provisional application · filed 7 Jul 2000
Application60/218,948Us provisional application · filed 14 Jul 2000
Application60/220,037Us provisional application · filed 21 Jul 2000
Application60/221,837Us provisional application · filed 28 Jul 2000
Application10/274,694Continuation · filed 18 Oct 2002
US 2003/0143589 A1This patent

From the US filing history. Foreign family members aren’t listed.