Breast cancer transcription factor gene and uses
AssigneeOrigene Technologies, Inc.
InventorsZairen Sun, Wufang Fan, Karl F. Kovacs, Xuan Li, Gilbert Jay
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Abstract
The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides, Urb-ctf, are expressed in breast cancer and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions especially related to breast cancer.
Claims27
An isolated human Urb-ctf polynucleotide which codes without interruption for an amino acid sequence set forth in SEQ ID NO 2, or a complement thereto.
An isolated human Urb-ctf polynucleotide comprising,
- polynucleotide sequence having 97% or more nucleotide sequence identity to the polynucleotide sequence set forth in SEQ ID NO 1, which codes without interruption for Urb-ctf, and which has transcriptional regulatory activity.
An isolated polynucleotide which is specific for human Urb-ctf and which codes for a polypeptide, said polypeptide comprising.
- amino acid 38 of SEQ ID NO 2,
- amino acid 68 of SEQ ID NO 2,
- amino acids 76-77 of SEQ ID NO 2,
- amino acid 119 of SEQ ID NO 2,
- amino acid 143-144 of SEQ ID NO 2,
- amino acid 161 of SEQ ID NO 2,
- amino acid 583 of SEQ ID NO 2,
- amino acid 606 of SEQ ID NO 2, or
- complements thereof.
Dependencies are inferred from the claim text.