Diagnosis and treatment of vascular disease

A method for identifying a subject who is a candidate for further diagnostic evaluation for a vascular disease or disorder comprising the steps of:

• a) determining the identity of the nucleotides present at nucleotide positions 157790 and 159908 of SEQ ID NO:1, or the complements thereof;
• and
• b) identifying the subject as a subject who is a candidate for further diagnostic evaluation for a vascular disease or disorder based on the identity of the nucleotides present at nucleotide positions 157790 and 159908 of SEQ ID NO:
• 1, or the complements thereof.

A method for selecting a clinical course of therapy to treat a subject who is at risk for developing a vascular disease or disorder comprising the steps of:

• a) determining the identity of the nucleotides present at nucleotide positions 157790 and 159908 of SEQ ID NO:
• 1, or the complements thereof;
• and
• b) selecting a clinical course of therapy for treatment of a subject who is at risk for developing a vascular disease or disorder based on the identity of the nucleotides present at nucleotide positions 157790 and 159908 of SEQ ID NO:1, or the complements thereof.

A method for determining whether a subject will benefit from implantation of a stent comprising the steps of:

• a) determining the identity of the nucleotides present at nucleotide positions 157790 and 159908 of SEQ ID NO:
• 1, or the complements thereof;
• and
• b) determining whether a subject will benefit from implantation of a stent based on the identity of the nucleotides present at nucleotide positions 157790 and 159908 of SEQ ID NO:
• 1, or the complements thereof.

A method for determining whether a subject will benefit from use of a vascular imaging procedure comprising the steps of:

• a) determining the identity of the nucleotides present at nucleotide positions 157790 and 159908 of SEQ ID NO:
• 1, or the complements thereof;
• and
• b) determining whether a subject will benefit from use of a vascular imaging procedure based on the identity of the nucleotides present at nucleotide positions 157790 and 159908 of SEQ ID NO:
• 1, or the complements thereof.

A method for determining whether a subject will benefit from a surgical procedure comprising the steps of:

• a) determining the identity of the nucleotides present at nucleotide positions 157790 and 159908 of SEQ ID NO:
• 1, or the complements thereof;
• and
• b) determining whether a subject will benefit from a surgical procedure based on the identity of the nucleotides present at nucleotide positions 157790 and 159908 of SEQ ID NO:
• 1, or the complements thereof.

A method for selecting an effective vascular imaging device as a diagnostic tool in a subject comprising the steps of:

• a) determining the identity of the nucleotides present at nucleotide positions 157790 and 159908 of SEQ ID NO:
• 1, or the complements thereof, and
• b) selecting an effective vascular imaging device as a diagnostic tool for said subject based on the identity of the nucleotides present at nucleotide positions 157790 and 159908 of SEQ ID NO:
• 1, or the complements thereof.

A network system for identifying whether or not a subject has a predisposition to a vascular disease or disorder, said system comprising means for:

• receiving information from the subject regarding the polymorphic region of an EDN1 gene,
• receiving phenotypic information associated with the subject,
• acquiring additional information from the network, and
• based on one or more of the phenotypic information, the polymorphic region, and the acquired information, determining whether or not the subject has a pre-disposition to a vascular disease or disorder associated with a polymorphic region of an EDN1 gene.

A method for determining whether a subject has a pre-disposition to a vascular disease or disorder associated with a polymorphic region of an EDN1 gene, said method comprising the steps of:

• receiving information associated with the polymorphic region of an EDN1 gene,
• receiving phenotypic information associated with the subject,
• acquiring information from the network corresponding to an EDN1 gene, and
• based on one or more of the phenotypic information, the polymorphic region, and the acquired information, determining whether the subject has a pre-disposition to a vascular disease or disorder associated with a polymorphic region of an EDN1 gene.

A method of diagnosing or aiding in the diagnosis of a vascular disease in a subject comprising the steps of:

• (a) obtaining a nucleic acid sample from the subject;
• and
• (b) determining the identity of the nucleotides at nucleotide positions 157790 and 159908 of SEQ ID NO:
• 1, or the complement thereof,
• wherein the presence at least one copy of a C at nucleotide position 157790 of GI 2791272 in combination with at least one copy of a G at nucleotide position 159908 of GI 2791272, or the complements thereof, or at least one copy of T at nucleotide position 157790 of GI 2791272 in combination with at least one copy of T at nucleotide position 159908 of GI 2791272, or the complements thereof, is indicative of increased likelihood of a vascular disease in the subject as compared with a subject having any other combination of these alleles.

A method for predicting the likelihood that a subject will have a vascular disease, comprising the steps of:

• (a) obtaining a nucleic acid sample from the subject;
• and
• (b) determining the identity of the nucleotides at nucleotide positions 157790 and 159908 of SEQ ID NO:
• 1, or the complement thereof,
• wherein the presence of at least one copy of a C at nucleotide position 157790 of GI 2791272, in combination with at least one copy of a G at nucleotide position 159908 of GI 2791272, or the complements thereof, or at least one copy of T at nucleotide position 157790 of GI 2791272, in combination with at least one copy of T at nucleotide position 159908 of GI 2791272, or the complements thereof, is indicative of increased likelihood of a vascular disease in the subject as compared with a subject having any other combination of these alleles.

A method of assessing a subject's risk for vascular disease, the method comprising:

• a) obtaining biological information from the individual;
• b) analyzing the information to obtain the subject's EDN1 genetic profile;
• c) representing the EDN1 genetic profile information as digital genetic profile data;
• d) electronically processing the EDN1 digital genetic profile data to generate a risk assessment report for vascular disease, wherein the presence of a polymorphic region of EDN1 indicates an increased risk for vascular disease;
• and
• e) displaying the risk assessment report on an output device.

A method of assessing a subject's risk for vascular disease, the method comprising:

• a) obtaining the subject's EDN1 genetic profile information as digital genetic profile data;
• b) electronically processing the EDN1 digital genetic profile data to generate a risk assessment report for vascular disease, wherein the presence of a polymorphic region of EDN1 indicates an increased risk for vascular disease;
• and
• c) displaying the risk assessment report on an output device.

A medical information system for assessing a subject's risk for vascular disease comprising:

• a) means for obtaining biological information from the individual to obtain an EDN1 genetic profile;
• b) means for representing the EDN1 genetic profile as digital molecular data;
• c) means for electronically processing the EDN1 digital genetic profile to generate a risk assessment report for vascular disease;
• and
• d) means for displaying the risk assessment report on an output device, wherein the presence of a polymorphic region of EDN1 indicates an increased risk for vascular disease.

A medical information system for assessing a subject's risk for vascular disease comprising:

• a) means for representing the subject's EDN1 genetic profile data as digital molecular data;
• b) means for electronically processing the EDN1 digital genetic profile to generate a risk assessment report for vascular disease;
• and
• c) means for displaying the risk assessment report on an output device, wherein the presence of a polymorphic region of EDN1 indicates an increased risk for vascular disease.

A method for a health care provider to generate a personal health assessment report for an individual, the method comprising counseling the individual to provide a biological sample;

• authorizing a draw station to take a biological sample from the individual and transmit molecular information from the sample to a laboratory company, wherein the molecular information comprises the presence or absence of a polymorphic region of EDN1;
• requesting the laboratory company to provide digital molecular data corresponding to the molecular information to a medical information system to electronically process the digital molecular data and digital health data obtained from the individual to generate a health assessment report;
• receiving the health assessment report from the medical information system;
• and providing the health assessment report to the individual.

A method of assessing the health of an individual, the method comprising:

• obtaining health information from the individual using an input device;
• representing at least some of the health information as digital health data;
• obtaining biological information from the individual, wherein the information comprises the presence or absence of a polymorphic region of EDN1;
• representing at least some of the information as digital molecular data;
• electronically processing the digital molecular data and digital health data to generate a health assessment report;
• and displaying the health assessment report on an output device.