Genetic changes in atypical nodular proliferations in congenital melanocytic nevi
AssigneeThe Regents of the University of California
InventorBoris C. Bastian
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Abstract
The invention provides methods of distinguishing benign growths arising from congenital melanocytic nevi from malignant melanoma. The methods comprise detecting a change in chromosome number that is specifically associated with benign growths. These changes include a gain of chromosome 10, a gain of chromosome 11, and a loss of chromosome 7.
Claims18
A method of typing a growth arising in association with a congenital melanocytic nevus, the method comprising providing a skin tumor sample from a patient and detecting a change in chromosome number in a nucleic acid sample from the skin tumor sample, wherein the change in chromosome number is selected from the group consisting of a gain of chromosome 10, a gain of chromosome 11, a loss of chromosome 7, or a combination thereof;
- thereby typing the skin tumor sample as a benign growth.
Dependencies are inferred from the claim text.