Method of drying blood plasma
AssigneeFraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V.
InventorsThomas Luck, Armin Prasch, Andreas Maurer, Reinhard Nowak, Bernard Luy
Life of this patent
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Abstract
The invention relates to a method of drying blood plasma, blood plasma fractions or blood plasma products (material for treatment) obtained therefrom, the product being sprayed in a liquid or dissolved condition into an evacuable container, drying to the granular form being carried out by means of a fluidizing gas in the fluidized layer.
Claims39
A method of drying blood plasma, comprising drying liquid blood plasma, devoid of any binders, fillers and carriers, to a granular form in a bed of a heated fluidizing gas, monitoring the temperature of said blood plasma being dried so as not to exceed a temperature that has been determined as the maximum acceptable temperature, or the highest temperature to which a particular plasma protein may be exposed with no loss of the biological activity known to be associated with said protein.
A method of drying liquid blood plasma, consisting of:
- a) providing a fluidized bed produced by a fluidizing gas;
- b) directly spraying said blood plasma devoid of any binders, fillers and carriers, into an evacuable chamber containing said fluidizing bed, thereby introducing said. blood plasma into said fluidized bed;
- c) drying said blood plasma to produce granules having a diameter of 100-200 μm, by raising the temperature of said blood plasma in said fluidized bed produced by said fluidizing gas;
- and
- d) further heating said granules for a period of time and to a temperature higher than that of step c), which is high enough to inactivate viruses but does not exceed the fixed maximum acceptable product temperature, while said dried blood plasma is still in said fluidized bed produced by said fluidizing gas.
A method of drying liquid blood plasma, consisting of:
- a) providing a fluidized bed produced by a fluidizing gas;
- b) directly spraying said blood plasma devoid of any binders, fillers and carriers, into an evacuable chamber containing said fluidizing bed, thereby introducing said blood plasma into said fluidized bed;
- c) drying said blood plasma to produce granules having a diameter of 100-200 μm by reducing the pressure within the evacuable container below 500 mbars, raising the temperature of said blood plasma in said fluidized bed produced by said fluidizing gas, and supplying an additional energy source, the heat transfer mechanism of which is not convective in nature, such as microwave radiation;
- and
- d) further heating said granules for a period of time and to a temperature higher than that of step c), which is high enough to inactivate viruses but does not exceed the fixed maximum acceptable product temperature, while said dried blood plasma is still in said fluidized bed produced by said fluidizing gas.
A method of drying liquid blood plasma fractions obtained by separating said fractions from liquid blood plasma, comprising drying said blood plasma fractions, devoid of any binders, fillers and carriers, to a granular form in a bed of a heated fluidizing gas, monitoring the temperature of said blood plasma fractions being dried so as not to exceed a temperature that has been determined as the maximum acceptable temperature, or the highest temperature to which a particular plasma protein known to be present in the blood plasma factions may be exposed with no loss of the biological activity known to be associated with the protein.
A method of drying liquid blood plasma fractions, consisting of:
- a) providing a fluidized bed produced by a fluidizing gas;
- b) directly spraying said blood plasma fractions devoid of any binders, fillers and carriers, into an evacuable chamber containing said fluidizing bed, thereby introducing said blood plasma fractions into said fluidized bed;
- c) drying said blood plasma fractions to p produce granules having a diameter of 100-200 μm, by raising the temperature of said blood plasma fractions in said fluidized bed produced by said fluidizing gas;
- and
- d) further heating said granules for a period of time and to a temperature higher than that of step c), which is high enough to inactivate viruses but does not exceed the fixed maximum acceptable product temperature, while said dried blood plasma fractions are still in said fluidized bed produced by said fluidizing gas.
A method of drying liquid blood plasma fractions, consisting of:
- a) providing a fluidized bed produced by a fluidizing gas;
- b) directly spraying said blood plasma fractions devoid of any binders, fillers and carriers, into an evacuable chamber containing said fluidizing bed, thereby introducing said blood plasma fractions into said fluidized bed;
- c) drying said blood plasma fractions to produce granules having a diameter of 100-200 μm by reducing the pressure within the evacuable container below 500 mbars, raising the temperature of said blood plasma fractions in said fluidized bed produced by said fluidizing gas, and supplying an additional energy source, the heat transfer mechanism of which is not convective in nature, such as microwave radiation;
- and
- d) further heating said granules for a period of time and to a temperature higher than that of step c), which is high enough to inactivate viruses but does not exceed the fixed maximum acceptable product temperature, while said dried blood plasma fractions are still in said fluidized bed produced by said fluidizing gas.
A method of drying liquid blood plasma products, obtained by purifying said products from liquid blood plasma fractions, comprising drying said blood plasma products, devoid of any binders, fillers and carriers, to a granular form in a bed of a heated fluidizing gas, monitoring the temperature of said blood plasma products being dried so as not to exceed a temperature that has been determined as the maximum acceptable temperature, or the highest temperature to which a particular protein known to be present in the blood plasma products may be exposed with no loss of the biological activity known to be associated with said protein.
A method of drying liquid blood plasma products, consisting of:
- a) providing a fluidized bed produced by a fluidizing gas;
- b) directly spraying said blood plasma products devoid of any binders, fillers and carriers, into an evacuable chamber containing said fluidizing bed, thereby introducing said blood plasma products into said fluidized bed;
- c) drying said blood plasma products to produce granules having a diameter of 100-200 μm, by raising the temperature of said blood plasma in said fluidized bed produced by said fluidizing gas;
- and
- d) further heating said granules for a period o of time and to a temperature higher than that of step c), which is high enough to inactivate viruses but does not exceed the fixed maximum acceptable product temperature, while said dried blood plasma products are still in said fluidized bed produced by said fluidizing gas.
A method of drying liquid blood plasma products, consisting of:
- a) providing a fluidized bed produced by a fluidizing gas;
- b) directly spraying said blood plasma products devoid of any binders, fillers and carriers, into an evacuable chamber containing said fluidizing bed, thereby introducing said blood plasma products into said fluidized bed;
- c) drying said blood plasma products to produce granules having a diameter of 100-200 μm by reducing the pressure within the evacuable container below 500 mbars, raising the temperature of said blood plasma products in said fluidized bed produced by said fluidizing gas, and supplying an additional energy source, the heat transfer mechanism of which is not convective in nature, such as microwave radiation;
- and
- d) further heating said granules for a period of time and to a temperature higher than that of step c), which is high enough to inactivate viruses but does not exceed the fixed maximum acceptable product temperature, while said dried blood plasma products are still in said fluidized bed produced by said fluidizing gas.
Dependencies are inferred from the claim text.