Topical treatment or prevention of ocular infections
AssigneeInsite Vision Incorporated
InventorsSamir Roy, Lyle M. Bowman
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Abstract
Azalide antibiotics such as azithromycin are useful in the treatment and prevention of infections by bacteria and other parasites. Stabilized aqueous compositions containing azithromycin suitable for administration without reconstitution are provided for. Also provided for are aqueous formulations suitable for ocular administration in a employing a convenient dosing formulation suitable for administration in depot formats.
Claims38
A composition comprising water and an azalide antibiotic, wherein said composition has a pH of about 5.0 to about 7.0.
A solid, semi-solid, powdered, or lyophilized composition comprising an azalide antibiotic, which upon addition of water produces an aqueous formulation having a pH from about 5.8 to about 7.0.
The composition according to claim 17, wherein said polymeric suspending agent is a lightly crosslinked carboxy vinyl polymer, and said pH upon reconstitution is from about 5.8 to about 6.8.
A method of preparing a stable azalide antibiotic composition for medicinal use, comprising the steps of:
- (a) dispersing or solubilizing an azalide antibiotic in an aqueous medium having a pH less than about 5.0;
- (b) adding abase to the composition formed in step (a);
- (c) adding water to the solution formed in step (b);
- and
- (d) adjusting the solution formed in step (c) to a pH of about 5.0 to about 7.0.
A method of treating a patient comprising administering a composition comprising an azalide antibiotic formulation having a pH from about 5.0 to about 7.0.
The method of 30, wherein said composition is injected into the eye.
The method of 30, wherein said composition is topically applied to the eye.
Dependencies are inferred from the claim text.