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US 2003/0143258 A1Published application
Bone graft
AssigneeOsteotech, Inc.
InventorsDavid Knaack, Kathy Traianedes, Michele Diegman, Nanette Forsyth, John Winterbottom
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AssigneeOsteotech, Inc.
InventorsDavid Knaack, Kathy Traianedes, Michele Diegman, Nanette Forsyth, John Winterbottom
Estimating the term…
An improved demineralized bone matrix (DBM) or other matrix composition is provided that has been mixed with a stabilizing agent that acts as (1) a diffusion barrier, (2) a enzyme inhibitor, (3) a competitive substrate, or (4) a masking moiety. A diffusion barrier acts as a barrier so as to protect the osteoinductive factors found in DBM from being degraded by proteolytic and glycolytic enzymes at the implantation site. Stabilizing agents may be any biodegradable material such as starches, modified starches, cellulose, dextran, polymers, proteins, and collagen. As the stabilizing agents degrades or dissolves in vivo, the osteoinductive factors such as TGF-β, BMP, and IGF are activated or exposed, and the activated factors work to recruit cells from the preivascular space to the site of injury and to cause differentiation into bone-forming cells. The invention also provides methods of preparing, testing, and using the inventive improved osteodinductive matrix compositions.
An implantable bone growth inducing composition comprising:
An implantable bone growth inducing composition comprising:
A demineralized bone matrix (DBM) composition comprising a demineralized bone matrix (DBM), and a stabilizing agent.
A demineralized bone matrix composition comprising demineralized bone matrix (DBM) and a diffusion barrier.
A demineralized bone matrix composition comprising:
A DBM composition comprising DBM and an excipient having at least 25% of the osteoinductivity of 10 μg BMP-collagen sponge preparation.
A method of preparing a demineralized bone matrix composition, the method comprising steps of:
A drug delivery device comprising:
The osteoinductive composition for implantation at a bone defect site which comprises osteoinductive demineralized bone matrix in a carrier of hydrated polysaccharide, the type and quantity of polysaccharide present in the carrier being sufficient, upon hydration, of importing flowability to the composition and providing an osteoinductive activity of at least 1 as measured by the athymic rat model assay.
A graft material comprising bone derived particles and starch or combination of starches.
A graft material comprising calcium phosphate particles, starch or combination of starches, and a biologically active factor.
A composition comprising demineralized bone matrix (DBM) and a stabilizing agent, wherein the stabilizing agent extends the half-life of the DBM activity in vivo.
A composition comprising DBM and an excipient, wherein the excipient slows the release rate or extends osteoinductivity lifetime of the DBM.
Dependencies are inferred from the claim text.