Helicobacter GHPO 1360 and GHPO 750 polypeptides and corresponding polynucleotide molecules
OwnerHarold Kleanthous, Ling Lissolo +3inventors
InventorsHarold Kleanthous, Ling Lissolo, Jean-Francois Tomb, Charles Miller, Amal Al-Garawi
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Abstract
The invention provides Helicobacter polypeptides, designated GHPO 1360 and GHPO 750, which can be used in vaccination methods for preventing or treating Helicobacter infection, and polynucleotides that encode these polypeptides.
Claims39
An isolated polynucleotide that encodes:
- (i) a polypeptide comprising an amino acid sequence that is homologous to the amino acid sequence of a Helicobacter polypeptide, wherein said amino acid sequence of said Helicobacter polypeptide is selected from the group consisting of the amino acid sequences as shown:
- in SEQ ID NO:2, beginning with an amino acid in any one of the positions from −20 to 5, and ending with an amino acid in position 279 (GHPO 1360);
- and
- in SEQ ID NO:4, beginning with an amino acid in position 1 and ending with an amino acid in position 399 (GHPO 750);
- or
- (ii) a derivative of said polypeptide encoded by said polynucleotide.
An isolated polynucleotide that encodes:
- (i) a polypeptide comprising an amino acid sequence that is homologous to an amino acid sequence selected from the group consisting of the amino acid sequences as shown:
- in SEQ ID NO:2, beginning with an amino acid in position −20 and ending with an amino acid in position 279 (GHPO 1360);
- and
- in SEQ ID NO:4, beginning with an amino acid in position 1 and ending with an amino acid in position 399 (GHPO 750);
- or
- (ii) a derivative of said polypeptide encoded by said polynucleotide.
A compound, in a substantially purified form, that is the mature form or a derivative of a polypeptide comprising an amino acid sequence that is homologous to a Helicobacter polypeptide having a sequence that is selected from the group consisting of the amino acid sequences as shown:
- in SEQ ID NO:2, beginning with an amino acid in position −20 and ending with an amino acid in position 279 (GHPO 1360);
- and
- in SEQ ID NO:4, beginning with an amino acid in position 1 and ending with an amino acid in position 399 (GHPO 750).
Dependencies are inferred from the claim text.