Multimeric forms of human rhinovirus receptor protein
OwnerJeffrey M. Greve, Alan Mcclellandinventors
Life of this patent
Estimating the term…
Abstract
The present invention relates to novel forms and configurations of intercellular adhesion molecule (ICAM) including multimeric configurations that effectively bind to human rhinovirus and can effectively reduce HRV infectivity. When in a multimeric configuration, preferably as dimers, these proteins display enhanced binding of HRV and are able to reduce HRV infectivity as well as the infectivity of other viruses known to bind to the “major” group human rhinovirus receptor (HRR). The multimerized proteins may also be used to block tICAM interaction with lymphocyte function-associated antigen-1 (LFA-1).
Claims43
Multimeric ICAM.
In a method for enhancing the binding of ICAM to a ligand, the improvement comprising the steps of:
- presenting said ICAM in a multimeric configuration.
A method for inducing irreversible uncoating of human rhinovirus, said method comprising contacting said human rhinovirus with ICAM-1 or a tICAM fragment thereof.
A method of irreversibly inhibiting infectivity of a mammalian cell by a human rhinovirus, said method comprising contacting said human rhinovirus with ICAM-1 or a tICAM fragment thereof under conditions which allow the ICAM-1 or tICAM to bind to said rhinovirus;
- thereby stimulating irreversible uncoating of said rhinovirus.
Dependencies are inferred from the claim text.