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US 2003/0143234 A1Published application
Anti-microbial targeting chimeric pharmaceutical
OwnerWenyuan Shi, Sherie L. Morrison +5inventors
InventorsWenyuan Shi, Sherie L. Morrison, Kham Trinh, Letitia Wims, Li Chen, Maxwell Anderson, Fengxia Qi
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Abstract
The present invention is based on the discovery of a composition that provides targeted anti-microbial effect. Specifically the composition contains a targeting moiety which recognizes a target microbial organism and an anti-microbial peptide moiety which has anti-microbial activity. In addition, the present invention provides methods of treating a microbial infection, e.g., on mucosal surfaces by using the compositions provided by the present invention.
Claims48
A composition useful for treatment of microbial organisms comprising
- a targeting moiety and
- an anti-microbial peptide moiety,
- wherein the targeting moiety is coupled to the anti-microbial peptide moiety and recognizes a target microbial organism and wherein the composition has an anti-microbial effect on the target microbial organism.
Dependencies are inferred from the claim text.