Methods and compositions for the treatment and diagnosis of pain disorders using 57749
AssigneeMillennium Pharmaceuticals, Inc.
InventorInmaculada Silos-Santiago
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Abstract
The present invention relates to methods and compositions for the treatment and diagnosis of pain disorders. The invention further provides methods for identifying a compound capable of treating a pain disorder. In addition, the invention provides a method for treating a subject having a pain disorder characterized by aberrant 57749 polypeptide activity or aberrant 57749 nucleic acid expression.
Claims13
A method for identifying a compound capable of treating a pain disorder, comprising assaying the ability of the compound to modulate 57749 nucleic acid expression or 57749 polypeptide activity, thereby identifying a compound capable of treating a pain disorder.
A method for identifying a compound capable of modulating a pain signaling mechanism comprising:
- a) contacting a cell which expresses 57749 with a test compound;
- and
- b) assaying the ability of the test compound to modulate the expression of a 57749 nucleic acid or the activity of a 57749 polypeptide, thereby identifying a compound capable of modulating pain signalling.
A method for modulating a pain signaling mechanism in a cell comprising contacting a cell with a 57749 modulator, thereby modulating a pain signaling mechanism in the cell.
A method for treating a subject having a pain disorder characterized by aberrant 57749 polypeptide activity or aberrant 57749 nucleic acid expression comprising administering to the subject a 57749 modulator, thereby treating said subject having a pain disorder.
Dependencies are inferred from the claim text.