FAPalpha -specific antibody with improved producibility
AssigneeBoehringer Ingelheim International GmbH
InventorsJohn Edward Park, Pilar Garin-Chesa, Uwe Bamberger, Wolfgang J. Rettig, Olivier Leger, Jose William Saldanha
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Abstract
Recombinant antibody proteins are provided that specifically bind fibroblast activation protein alpha (FAPα) and comprise framework modifications resulting in the improved producibility in host cells. The invention also relates to the use of said antibodies for diagnostic and therapeutic purposes and methods of producing said antibodies.
Claims73
An antibody protein having the complementary determining regions of the monoclonal antibody F19 (ATCC Accession No. HB 8269), said antibody protein specifically binding to fibroblast activation protein, characterised in that it has framework modifications resulting in the improved producibility in host cells as compared to a chimeric antibody having the variable regions of F19 and foreign constant regions.
An antibody protein containing an amino acid sequence as set forth in SEQ ID NO:2.
Dependencies are inferred from the claim text.