Immune cell cytokine
AssigneeHuman Genome Sciences, Inc.
InventorsYi Li, Daniel R. Soppet
Life of this patent
Estimating the term…
Abstract
Human Immune Cell Cytokine-like Hormone polypeptide and DNA (RNA) encoding such polypeptide in a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for stimulating the proliferation and differentiation of stem cells of the immune system. Antagonists against such polypeptides are also disclosed. The antagonists include antibodies which may be employed as a therapeutic to treat leukemia and lymphoblastoma, may also be used as imaging agents and diagnostic agents for detecting expression levels of the protein. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides.
Claims25
An isolated polynucleotide comprising a polynucleotide having at least 70% identity to a member selected from the group consisting of:
- (a) a polynucleotide encoding a polypeptide comprising the amino acid sequence of SEQ ID NO:2;
- (b) a polynucleotide encoding a polypeptide comprising amino acids 21 to 337 of SEQ NO ID:2;
- (c) a polynucleotide which is complementary to the polynucleotide of (a);
- and
- (d) a polynucleotide comprising at least 15 consecutive bases of the polynucleotide of (a), (b) or (c).
An isolated polynucleotide comprising a polynucleotide having at least a 70% identity to a member selected from the group consisting of:
- (a) a polynucleotide encoding a mature HLHDC84 polypeptide expressed by the human cDNA contained in ATCC Deposit No. 97351;
- (b) a polynucleotide complementary to the polynucleotide of (a);
- and
- (c) a polynucleotide comprising at least 15 bases of the polynucleotide of (a) or (b).
A polypeptide comprising a member selected from the group consisting of:
- (a) a polypeptide comprising an amino acid sequence as set forth in SEQ ID NO:2;
- (b) a polypeptide comprising amino acids 21 to 337 of SEQ ID NO:2;
- (c) a polypeptide which is at least 70% identical to the polypeptide of (a) or (b);
- and
- (d) a polypeptide having at least 15 amino acid residues of the polypeptide of (a), (b) or (c).
A polypeptide comprising amino acids 21 to 337 of SEQ ID NO:2.
Dependencies are inferred from the claim text.