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AssigneeCrossbeta Biosciences B.V.
InventorsManuel Castro Cabezas, Hans van Dijk
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Complement is recognized as an important, humoral defense system involved in the innate (nonspecific) recognition and elimination of microbial invaders, other foreign particles or molecules, and antigen-antibody complexes from the body. The present invention makes use of the surprising notion that the handling of lipids by the body, rather than its antimicrobial activity, is the primary and most ancient function of the complement system. Consequently, atherosclerosis as observed in disorders associated with disturbed lipid metabolism (familial combined hyperlipemia (FCHL), postprandial hyperlipidemia, hypertriglyceridemia with low levels of HDL cholesterol, and insulin resistance associated with type-II diabetes and obesity), is ascribed to either genetic or acquired defects in ancient (activatory and/or regulatory) complement components. Based on this new insight, novel preventive measures and treatment modalities of disturbed lipid metabolism are introduced.
A method for the treatment and/or prophylaxis of diseases associated with disturbances in the complement/lipid pathway, said method comprising:
The method according to any one of the preceding claims, wherein said modulating the activity of one or more elements is achieved through administering one or more modulators to the subject.
A method for diagnosing disturbances in the complement/lipid pathway or an underlying or related defect of atherosclerosis, said method comprising:
A method for diagnosing the anti-atherogenic potential of at least one human, recombinant, natural and/or (semi)synthetic modulator or a functional equivalent thereof, said method comprising:
A composition for the treatment and/or prophylaxis of diseases selected from the group consisting of diseases associated with disturbances in the complement/lipid pathway, atherosclerosis and/or an underlying and/or a related disease associated with disturbances in the complement/lipid pathway, and disturbances of lipid metabolism, said composition comprising:
Dependencies are inferred from the claim text.