Hybrid immunoglobulins
AssigneeGenentech, Inc.
InventorsDaniel J. Capon, Laurence A. Lasky
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Abstract
Novel polypeptides are provided, together with methods for making and using them, and nucleic acids encoding them. These polypeptides are useful as cell surface adhesion molecules and ligands, and are useful in therapeutic or diagnostic compositions and methods.
Claims49
A polypeptide fusion comprising a ligand binding partner protein and a stable plasma protein, wherein the ligand binding partner protein is not a platelet growth factor receptor or an insulin receptor.
A polypeptide fusion comprising a first ligand binding partner and a stable plasma protein, said fusion further comprising an additional fusion of a second ligand binding partner and a second stable plasma protein, wherein said first and second ligand binding partners are different.
A polypeptide fusion comprising a ligand binding partner and a stable plasma protein, wherein said stable plasma protein is not an immunoglobulin.
A polypeptide fusion comprising a ligand binding partner and a stable plasma protein, said fusion comprising a single chain fusion.
A polypeptide fusion comprising a first ligand binding partner and a stable plasma protein, said fusion further comprising an additional fusion of a second ligand binding partner and a second stable plasma protein, wherein each of said stable plasma proteins are immunoglobulin constant domains.
Dependencies are inferred from the claim text.