Chitinase chitin-binding fragments
OwnerPatrick W. Gray, Larry W. Tjoelkerinventors
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Abstract
The present invention provides chitin-binding fragments of human chitinase, fragment analogs, purified and isolated polynucleotide sequences encoding such fragments and analogs, and materials and methods for the recombinant production of human chitinase fragment products which are expected to be useful as in products for detecting chitin, binding chitin, and treating fungal infections or for development of products useful for treating the same.
Claims24
A chitin-binding, chitinase-inactive polypeptide comprising a chitin-binding fragment of the 54 C-terminal amino acids of human chitinase as set forth in SEQ ID NO:
- 2.
A polypeptide selected from the group consisting of polypeptides having the sequence of amino acid residues X through Y of SEQ ID NO:
- 2, wherein X is a consecutive integer from 347 through 397 and Y is 445.
A monoclonal antibody that specifically binds to an epitope within the 54 C-terminal amino acids of human chitinase as set forth in SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.