Aqueous enzymatic denture adhesives
AssigneeLaclede, Inc.
InventorsMichael A. Pellico, Harjinder Kang
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Abstract
Hydro-activated and/or oxygen activated aqueous, enzymatic, antimicrobials denture adhesive compositions are stabilized against enzymatic action prior to oral application of the adhesive by incorporating a thickener into the adhesive formulation so as to provide the forrmulation with an enzyme immobilizing viscosity which inhibits enzymatic action during processing and in the adhesive package. An illustrative, thickened, enzymatic adhesive with this enhancement contains glucose oxidase, glucose, lactoperoxidase and potassium thiocyanate together with a mixture of polyacrylic acid and polyvinylpyrrolidone in an amount to provide the adhesive with a viscosity of at least about 300,000 centipoises.
Claims16
An aqueous, enzymatic denture adhesive composition having a water content of at least about 10 wt. % and containing, per gram of adhesive, from about 0.015 to about 0.6 millimole of oxidizable substrate and from about 0.5 to about 5,000 International Units of oxidreductase enzyme specific to such substrate for producing hydrogen peroxide upon oral application of the adhesive;
- and
- further containing non-toxic, ambient, water soluble thickener in an amount to provide the adhesive with a viscosity from about 300,000 to about 1,900,000 centipoises to thereby stabilize the adhesive against the production of hydrogen peroxide prior to oral application of the adhesive.
Dependencies are inferred from the claim text.