Tissue implants and methods for making and using same
OwnerGiuseppe Intini, Sebastiano Andreana +2inventors
InventorsGiuseppe Intini, Sebastiano Andreana, Rosemary Dziak, Libuse Anna Bobek
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Abstract
The invention provides biocompatible, biodegradable calcium sulfate matrices containing calcium sulfate activated platelets for use in tissue formation. The matrices are particularly useful in stimulating hard tissue, for example, bone formation. The matrices may also further include a growth factor and/or a transfectable gene, the inclusion of which may be useful in stimulating the growth of tissue of interest.
Claims51
A method of activating platelets comprising:
- (a) providing a platelet-containing fluid sample at a first temperature;
- and
- (b) adding to the sample, an amount of an exothermic salt sufficient to activate the platelets.
A method of promoting bone formation at a preselected locus in a mammal, comprising:
- providing to the locus a bioactive matrix comprising calcium sulfate and calcium sulfate activated platelets, wherein the bioactive matrix promotes bone formation at the locus.
A bioactive matrix comprising:
- a mixture of crystalline calcium sulfate and calcium sulfate activated platelets.
A bioactive matrix comprising:
- (i) a first domain defining an outer surface and comprising crystalline calcium sulfate and platelet-rich plasma, and optionally further comprising a first growth factor;
- and
- (ii) disposed upon the outer surface of the first domain, a second domain comprising crystalline calcium sulfate and platelet-rich plasma, and optionally further comprising a second, different growth factor,
- provided that at least one of the first domain and the second domain comprises a growth factor.
Dependencies are inferred from the claim text.