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US 2003/0143208 A1Published application
Oxidative stress-resistant cell lines and methods of use thereof
OwnerHaralambos Ischiropoulosinventor
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Abstract
Novel oxidative stress-resistant cell lines are provided. Such cell lines may be used to advantage in methods for the treatment neurodegenerative disorders associated with oxidative damage and subsequent neuronal cell loss, including, but not limited to, Parkinson's disease and head trauma.
Claims17
An oxidative stress-resistant cell line.
The oxidative stress-resistant cell line is a human oxidative stress-resistant cell line.
A method for obtaining an oxidative stress-resistant cell line, comprising the steps of:
- a) seeding cells in culture for a suitable time period to allow said cells to undergo at least one round of cell division;
- b) contacting said cells with at least one reactive oxygen and nitrogen species;
- c) propagating said cells in the presence of said reactive oxygen and nitrogen species;
- and
- d) isolating said cells that survive in the presence of said reactive oxygen and nitrogen species.
2 more elements
Dependencies are inferred from the claim text.