Anemia
OwnerKatie (Mary) Binley, Susan Mary Kingsman +1inventors
InventorsKatie (Mary) Binley, Susan Mary Kingsman, Stuart Naylor
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Abstract
Disclosed is a vector containing a nucleic acid sequence encoding erythropoietin (Epo) in operable linkage with an HRE expression control sequence, as well as uses thereof; for instance, in preparing a medicament, as well as in methods for treating anemia in a patient in need thereof. The method can involve administering to the patient a vector comprising a nucleic acid sequence encoding erythropoietin (Epo) in operable linkage with an HRE expression control sequence, wherein expression of Epo is physiologically regulated such that hematocrit levels of the patient are corrected and maintained.
Claims23
A method for treating anemia in a patient in need thereof, the method comprising, administering to said patient, a vector comprising a nucleic acid sequence encoding erythropoietin (Epo) in operable linkage with an HRE expression control sequence, wherein expression of Epo is physiologically regulated such that hematocrit levels of said patient are corrected and maintained.
A vector system comprising a nucleic acid sequence encoding erythropoietin (Epo) in operable linkage with an HRE expression control sequence, wherein the HRE expression control sequence includes two or more HRE expression control sequences;
- and, the vector system, when administered to a host, provides for physiological regulation of Epo.
Dependencies are inferred from the claim text.